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A measurement of electron antineutrino oscillation by the Daya Bay Reactor Neutrino Experiment is described in detail. Six 2.9-GWth nuclear power reactors of the Daya Bay and Ling Ao nuclear power facilities served as intense sources of ν e 's. Comparison of theν e rate and energy spectrum measured by antineutrino detectors far from the nuclear reactors (∼1500-1950 m) relative to detectors near the reactors (∼350-600 m) allowed a precise measurement ofν e disappearance. More than 2.5 millionν e inverse beta-decay interactions were observed, based on the combination of 217 days of operation of six antineutrino detectors (December, 2011-July, 2012) with a subsequent 1013 days using the complete configuration of eight detectors (October, 2012-July, 2015. Theν e rate observed at the far detectors relative to the near detectors showed a significant deficit, R ¼ 0.949 AE 0.002ðstatÞAE 0.002ðsystÞ. The energy dependence ofν e disappearance showed the distinct variation predicted by neutrino oscillation. Analysis using an approximation for the three-flavor oscillation probability yielded the flavor-mixing angle sin 2 2θ 13 ¼ 0.0841 AE 0.0027ðstatÞ AE 0.0019ðsystÞ and the effective neutrino mass-squared difference of jΔm 2 ee j ¼ ð2.50 AE 0.06ðstatÞ AE 0.06ðsystÞÞ × 10 −3 eV 2 . Analysis using the exact three-flavor probability found Δm

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