The mode of action of cyflumetofen is to inhibit mitochondria complex II by affecting its action site after being metabolised to AB-1. However, inhibition by cyflumetofen and AB-1 in other organisms was very weak. Selectivity for other organisms has contributed to differences in action site activities.

Cy umetofen is a novel benzoylacetonitile acaricide developed by Otsuka AgriTechno Co., Ltd. It has excellent e cacy against a variety of mites that attack fruits, nuts, vegetables, tea, and ornamentals. In addition, cy umetofen exhibited long persistence e cacy against mites. e new and unique chemistry of cy umetofen provides e ectiveness against mites that have developed resistance to existing acaricides. Extensive studies have shown that cy umetofen inhibits the mitochondrial electron-transport function of complex II, which is a novel target for the mode of action among pesticides. ese ndings suggest that cy umetofen could be an ideal component for integrated pest management (IPM) programs and resistant management programs because it is signi cantly safe for non-target organisms such as natural enemies and bene cial arthropods, and for the environment.