ORONARY HEART DISEASE (CHD) is a major cause of disability and premature death throughout the world. 1 Epidemiological studies have demonstrated an inverse association between physical fitness and the incidence of CHD or allcause mortality in healthy or asymptomatic participants. Physical fitness is typically expressed as cardiorespiratory fitness (CRF) and is assessed by exercise tolerance testing 2 ; however, it is rare for clinicians to consider CRF when evaluating future risk of CHD. 3 A major reason for lack of consideration of CRF as a marker of CHD risk may be that the quantitative association of CRF for cardiovascular risk is not well established. The degree of risk reduc-CME available online at www.jamaarchivescme.com and questions on p 2053.

S-1 is an effective adjuvant treatment for East Asian patients who have undergone a D2 dissection for locally advanced gastric cancer. (ClinicalTrials.gov number, NCT00152217 [ClinicalTrials.gov].).

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On the basis of 5-year follow-up data, postoperative adjuvant therapy with S-1 was confirmed to improve overall survival and relapse-free survival in patients with stage II or III gastric cancer who had undergone D2 gastrectomy.