Background: This study was undertaken to investigate the effect of intraradicular dentin pretreatment with silver nanoparticles (SNPs), zinc oxide nanoparticles (ZNPs), and titanium oxide nanoparticles (TNPs) on the push-out bond strength (PBS) of fiber posts to root dentin using two types of resin cements. Material and Methods: Eighty single-rooted human premolar roots were randomly divided into eight groups after endodontic treatment and post space preparation, according to the type of intraradicular dentin pretreatment with different nanoparticle solutions (n=20). The groups included no pretreatment (control) and pretreatments with SNPs, ZNPs, and TNPs. Each group was divided into 2 subgroups (n=10) according to cementation: Excite DSC/ Variolink II and ED Primer II/Panavia F2.0. The PBS values were measured in different areas of the post space. The data were subjected to the three-way analysis of variance and Tukey tests (p=0.05). Results: The SNP-pretreated groups showed significantly higher PBS values than the other groups. No significant differences in PBS were noted among the control, ZNP-pretreated, and TNP-pretreated groups. There was no significant difference in the PBS of the fiber posts with respect to cement type. The PBS was significantly lower in the apical region than in the other two regions. There was no statistically significant difference between the PBSs of the cervical and middle thirds. Conclusions: Intraradicular dentin pretreatment with SNPs, TNPs, and ZNPs did not interfere with the PBS of the fiber posts. The best result was obtained for the SNP-pretreated groups for both types of cement. Also, the lowest PBS was found in the apical third of the root canal spaces.