The aim of this study was to investigate the presence of tetracycline and florfenicol residues in broiler meat that sailed in Aydın city, Turkey. For this purpose, 80 broiler meats that brands of local and national commercial were used. ELISA technique was used to investigate the presence of antibiotic residues and liquid chromatography/ tandem mass spectrometry (LC-MS/MS) technique was used to confirm the residue. As result of the ELISA, 24 samples 30%) were positive for tetracycline. Florfenicol residues were found in any of the samples. 24 samples that is confirmed by LC-MS/MS were included an average of 30 ppb level. Residual amounts of the samples were found to be below the maximum residue limit (MRL) values.