Purpose: Here, we evaluated the safety and effectiveness of Jeonnam's unique resources, such as Dendropanax, sea salt, spinach, and kelp, to develop functional cosmetics that may alleviate hair loss. Methods: We performed safety tests with these resources, testing for heavy metals and cytotoxicity, and we evaluated their effectiveness as anti-microbial, cell proliferation, and anti-inflammation products. Results: The heavy metals concentration was lower than or in trace levels, as recommended by the Ministry of Food and Drug Safety's standard of extracts such as Dendropanax, sea salt, etc. We confirmed cytotoxicity to be safe. In each extract, the concentrations of Dendropanax, sea salt, spinach, and kelp were 0.01 mg/mL, 5 mg/mL, 0.5 mg/mL, 0.5 mg/mL, respectively. Only the Dendropanax extract had microbial effect, with the distilled water extract reaching the highest effect. The cell proliferation increased to 0.5 mg/mL, 5 mg/mL, and 2 mg/mL for Dendropanax, spinach, and kelp with distilled water extract, the anti-inflammation effect increased. Conclusion: We found that Dendropanax, sea salt, spinach, and kelp were safe and effective as functional cosmetic materials to alleviate hair loss symptoms through optimal standardization. We suggest further research to evaluate these cosmetics' functional effects.
