A simple, rapid, efficient, and environmentally benign procedure for synthesis of 2-pyrazoline derivatives has been achieved by reacting 2 ? -hydroxychalcones with hydrazine hydrate under solvent-free grinding technique.The short reaction time, cleaner reaction, easy workup, higher yields, and mild reaction conditions make this protocol practical and economically attractive in comparison with the classical reaction.

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Condensation of Schiff bases (III), derived from iodovanillin (I) and aromatic amines, with mercaptoacetic acid or chloroacetyl chloride provides the new thiazolidinones (V) and azetidinones (VII), respectively. These heterocycles show only weak or moderate antimicrobial activity at best. -(PAWAR, R. P.; ANDURKAR, N. M.; VIBHUTE, Y. B.; J. Indian Chem.