Highlights d Epidermal Nrg167 and the neuronal Nrg180 isoform interact with and stabilize each other d Epidermal Nrg167 supports dendrite growth and promotes dendrite enclosure d Epidermal Nrg167 prevents dendrite bundling by blocking Nrg180-Nrg180 interactions d Internalization of surface Nrg180 dissociates dendritedendrite binding
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