A diastereoselective approach to access cis‐pyrido and pyrrolo[1,2‐c][1,3]oxazin‐1‐ones has been developed through a one‐pot BF3.Et2O‐catalyzed [4+2] process starting with N,O‐acetals and terminal alkynes. In addition, the utility of this transformation is demonstrated by the scalable synthesis of (+)‐Febrifugine in 7 steps from the N,O‐acetal (15% overall yield).

Asymmetric Synthesis of Emericellamide B. -The title compound is prepared in a sequence of 17 linear steps and 9.4% overall yield. A general method for the total synthesis of emericellamide analogues is established. -(REN, R.-G.; MA, J.-Y.; MAO