Meyeniines A–C (1–3), three new lignans, two known neolignans (4–5), and three known lignans (6–8) were isolated from the rhizomes of Lepidium meyenii. Their structures were identified by comprehensive spectroscopic analyses and computational methods. Compound 1 represents a unique lignan featuring an aromatic ring migration. Compounds 2 and 4–6 were analyzed by chiral HPLC column as enantiomers. Biological evaluation revealed that compound 8 could inhibit IL‐6 production in lipopolysaccharide (LPS) induced RAW264.7 cells in a dose‐dependent manner.
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