Dendrobium nobile is a traditional Chinese medicine and functional food in China, containing phenanthrene, alkaloids, bibenzyl, sesquiterpenes, polysaccharides and other chemical components, with anti-aging, immunity-enhancing, glucose-lowering and lipid-lowering health functions. In recent years, the research value of D. nobile has attracted the attention of more and more experts and scholars. This paper reviews the chemical constituents isolated and identified from D. nobile and provides reference for further development and utilization of D. nobile.