A broad-spectrum fluorescent probe, which can be applied to monitoring HS in various biological systems, has been rationally designed and synthesized. This specific probe was applied to localize the endogenous HS in living Raw264.7 macrophage cells, HepG2 cells, and H9C2 cells. At the same time, the probe has successfully visualized CBS- and CSE-induced endogenous HS production and monitored CBS and CSE activity in H9C2 cells. This probe could serve as a powerful molecular imaging tool to further explore the physiological function and the molecular mechanisms of endogenous HS in living animal systems.

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