Karst Rocky Desertification (KRD) is the reduction of vegetative productivity of this land with the release of bedrock as a result of the full or partial transportation of the fertile soil through natural processes and human activities in karst landscapes. The purpose of this study is to reveal the effectiveness of Remote Sensing methods in monitoring, mapping, and evaluating KRD. Landsat 8 OLI images were used to carry out these procedures. In monitoring this process, Karst Bare Rock Index (KBRI), Normalized Difference Rock Index (NDRI), Carbonate Rock Index 2 (CRI2), Normalized Difference Build-Up Index (NDBI), Normalized Difference Vegetation Index (NDVI), Dimidiate Pixel Model (DPM), Multi Endmember Spectral Mixture Analysis (MESMA) and Support Vector Machine (SVM) were used from the spectral indices. In order to evaluate the results obtained, KRD was divided into 4 basic classes such as none, mild, moderate, and severe. According to these classification levels, it was determined that SVM method had the highest accuracy. For this reason, it was concluded that the SVM method can be used effectively in determining KRD. In the study, it was concluded that the KRD strengthens as one goes from south to north and from west to east in the research area. This study points out KRD is one of the effective land problems in the Mediterranean region, Turkey.