Exploring the "lung-intestine"axis of gut microbiota is a hot spot in recent years. There have been few studies on the correlation between gut microbiota and asthma and allergies, of which gut microbiota-mediated molecular regulation of the pathogenesis of infectious pathogens is a blind area. Therefore, we investigated gut microecological changes in MPP patients and the gut microecological characteristics of wheezing MPP pediatric patients.30 healthy children, 50 nonwheezing MPP pediatric patients, and 50 wheezing MPP pediatric patients were collected. 16srDNA gene sequencing results showed that there are differences in gut microbiota abundances between MPP pediatric patients and healthy children. Quantitative real-time polymerase chain reaction (QRT-PCR) validation showed that the abundances of Ruminococcus flavefaciens, Clostridium butyricum, Lactobacillus, and Bifidobacterium in the guts of MPP children decreased compared with healthy children. Compared with nonwheezing MPP children, the abundances of Ruminococcus flavefaciens and Clostridium butyricum were significantly decreased in the guts of wheezing MPP children. This indicates that Ruminococcus flavefaciens and Clostridium butyricum are significantly decreased in nonwheezing MPP children and could be potential risk factors for wheezing in MPP children.