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We report here, and rationalize, a synergistic effect between a non-noble metal oxide catalyst (CuO) and high frequency ultrasound (HFUS) on glucose oxidation. While CuO and HFUS are able to independently oxidize glucose to gluconic acid, the combination of CuO with HFUS led to a dramatic change of the reaction selectivity, with glucuronic acid being formed as the major product. By means of DFT calculations, we show that, under ultrasonic irradiation of water at 550 kHz, the surface lattice oxygen of a CuO catalyst traps H• radicals stemming from the sonolysis of water, making the ring opening of glucose energetically non-favorable and leaving a high coverage of •OH radical on the CuO surface which selectively oxidize glucose to glucuronic acid. This work also points towards a path to optimize the size of the catalyst particle for an ultrasonic frequency which minimizes the damage to the catalyst, resulting in its successful reuse.

Since the last IAEA Fusion Energy Conference in 2018, significant progress of the experimental program of HL-2A has been achieved on developing advanced plasma physics, edge localized mode (ELM) control physics and technology. Optimization of plasma confinement has been performed. In particular, high-N H-mode plasmas exhibiting an internal transport barrier have been obtained (normalized plasma pressure N reached up to 3). Injection of impurity improved the plasma confinement. ELM control using resonance magnetic perturbation (RMP) or impurity injection has been achieved in a wide parameter regime, including Types I and III. In addition, the impurity seeding with supersonic molecular beam injection (SMBI) or laser blow-off (LBO) techniques has been successfully applied to actively control the plasma confinement and instabilities, as well as the plasma disruption with the aid of disruption prediction. Disruption prediction algorithms based on deep learning are developed. A prediction accuracy of 96.8% can be reached by assembling convolutional neural network (CNN). Furthermore, transport resulted from a wide variety of phenomena such as energetic particles and magnetic islands have been investigated. In parallel with the HL-2A experiments, the HL-2M mega-ampere class tokamak was commissioned in 2020 with its first plasma. Key features and capabilities of HL-2M are briefly presented.

Background: Endometrial carcinoma (EC) still threatens the health of women. Thus, to explore how long intergenic non-protein coding RNA 01220 regulates the development of EC. Methods: Whole genome expression profile data of EC and paracancerous tissues in TCGA database were downloaded. LINC01220 expression in EC and paracancerous tissues of patients in our hospital were detected by qRT-PCR. Furthermore, the relationship between LINC01220 expression and clinicopathological features of EC patients was analyzed. After transfection with sh-LINC01220 and pcDNA-MAPK11 (mitogen-activated protein kinase) in EC cells, proliferative, colony formation abilities and apoptosis were determined by cell counting kit-8 (CCK-8), colony formation assay and flow cytometry, respectively. Western blot was conducted to determine the regulatory role of LINC01220 on MAPK11. Results: TCGA data showed that LINC01220 expression is markedly higher in EC tissues than that of paracancerous tissues, which was consistent without detection in EC patients of our hospital. LINC01220 expression was positively correlated to pathological grade and International Federation of Gynecology and Obstetrics (FIGO) stage of EC patients. After knockdown of LINC01220 in EC cells, proliferative and colony formation abilities decreased, whereas apoptotic rate increased. Cor function analysis revealed the positive correlation between LINC01220 and MAPK11 in EC. MAPK11 expression was regulated by LINC01220 in EC cells. Overexpression of MAPK11 can reverse the tumor suppressing effect of LINC01220 on EC. Conclusions: LINC01220 promotes EC development by stimulating proliferation and inhibiting apoptosis of EC cells through up-regulating MAPK11.