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Currently, advanced biomaterial design solutions often have more than two kinds of nanotechnology design strategies, but there is no suitable classification to describe these designs systematically. Based on the material design ideas and the modes of implementing functions, this article exemplifies and proposes a new nanotechnology classification that includes physical properties, the chemical reactions that respond to the microenvironment and bio-inspired incorporation. If two or more nanotechnology designs in the same classification are to be integrated into the same biological material, it is necessary to analyze the integration conflict between the designs. With the development of big data, this classification method may help researchers and artificial intelligence to realize automated integration of multiple designs and provide new material nanotechnology design integration solutions.

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Vascular stent service involves complex service environments and performance requirements, among which the histocompatibility of the stent could seriously affect the therapeutic effect. In the pathology of vascular disease, the thin fiber cap is easily ruptured, exposing the necrotic core below, and triggering a series of dangerous biochemical reactions. In contrast, the thin neointima, considered an essential structure growing on the stent, may evolve into vulnerable plaque structures due to lesions induced by the stent. Therefore, the reduction of necrosis around the stent below the thin neointima is indispensable. In this work, different cell model experiments suggested that the content of endogenous labile Zn positively correlated with cell injury. Zinquin-Zn fluorescence experiments and zinc ion channels research suggested that the change in the content of endogenous labile Zn in smooth muscle cells is affected by different stent coatings. The content of endogenous labile Zn in cells negatively correlated with cell viability. Animal experiments indirectly verified the increase in endogenous labile Zn by detecting the expression of Zn regulatory protein (metallothionein) in the necrotic tissues. Reducing the content of endogenous labile Zn may favor a reduction in smooth muscle cell injury and necrosis. This biochemical mechanism is effective in improving the therapeutic effect of vascular stents.