Methamphetamine (METH) is a psychostimulant abused around the world. Emerging evidence indicates that METH causes brain damage. However, there are very few reports on METH-induced demyelination. Thioredoxin-1 (Trx-1) is a redox regulating protein and plays the roles in protecting neurons from various stresses. However, whether Trx-1 resists demyelination induced by METH has not been reported. In this study, we found that METH-induced thin myelin sheaths in spinal cord, whereas Trx-1 overexpression transgenic (TG) mice restored the myelin sheaths thickness. The expressions of myelin-associated glycoprotein, myelin basic protein, and cyclin-dependent kinase 5 were decreased by METH, whereas these alterations were blocked in Trx-1 TG mice. The expressions of procaspase-12 and procaspase-3 were decreased by METH, the expression of calpain1 was increased by METH, whereas the alterations were suppressed in Trx-1 TG mice. As same as, the expressions of the extracellular signal-regulated kinase, nuclear factor κB, tumor necrosis factor-alpha, and interleukin-1beta were induced by METH, which were suppressed in Trx-1 TG mice. These data suggest that Trx-1 may play a critical role in resisting the METH-mediated demyelination in spinal cord through regulating endoplasmic reticulum stress and inflammation pathways.

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With the rapid development of China’s economy, the construction industry has entered a period of rapid development. The large-scale urbanization process has brought unprecedented demand for new buildings. BIM technology is an emerging engineering digital design method in the architectural design industry in recent years. By building an architectural information model, the comprehensive and comprehensive civil engineering design, related inspection and pipe network control can be realized. From the overview of BIM technology and the analysis of the characteristics of BIM technology, this paper analyzes the application of BIM technology in energy conservation.

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In recent years, the computer simulation technology has been widely studied, among which the seismic reliability theory of the structure and the seismic performance evaluation of the structure is widely concerned. The seismic reliability analysis of structures is of great significance to the seismic performance evaluation, design and decision of structures. Taking earthquake action as a random process and using random vibration theory to study the probabilistic characteristics is an important development of structural seismic theory. In the more than half a century since Housner first used stochastic processes in 1947, the random vibration theory has been applied and developed rapidly in engineering seismic analysis, and has increasingly become a more advanced and reasonable seismic analysis tool.