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Conflicts of interestList any present or potential conflict s of interest for all authors. (This field may be published.)The authors declare no potential conflict of interest.Author contributions (This field may be published.) Xin Sun conceived the idea and designed the study. Yinyan Shi and Borhan Mohammad wrote the manuscript. Jennifer Young, David Newman, Xiaochan Wang, Eric Berg and Xin Sun reviewed the manuscript and provide the editing suggestion. All authors approved the final version of manuscript. Ethics approval (IRB/IACUC) (This field may be published.) This manuscript does not require IRB/IACUC approval because there are no human and animal participants.