During crises, the ability to access relevant information is extremely important for those affected. Previous research shows that social media have become popular for rapid information exchange between members of the online community after crisis events. This study focuses on the effects of proximity to a crisis on information sharing behaviors. Using constructivist grounded theory to guide our inquiry, we conducted interviews with eleven people who used social media in the aftermath of the 2013 Boston Marathon Bombings. Salient themes emerging from this study suggest that both physical and emotional proximity to a crisis influence online information seeking and sharing behaviors. Additionally, speed of information sharing and information access renders social media especially useful during crisis and particularly susceptible to the spread of misinformation. We view the latter as a consequence of the inevitable sensemaking process that occurs as individuals attempt to make sense of incomplete information.

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Lung metastasis, the most frequent metastatic pattern in hepatocellular carcinoma, is an important contributor to poor prognosis. However, the mechanisms responsible for lung metastasis in hepatocellular carcinoma remain unknown. Aiming to explore these mechanisms, weighted gene coexpression network analysis (WGCNA) was firstly used to find hub genes related to lung metastasis. Then, we obtained 67 genes related to lung metastasis in hepatocellular carcinoma which were mainly related to ribosomal pathways and functions, and a protein interaction network analysis identified that fibrillarin (FBL) might be an important hub gene. Furthermore, we found that FBL is highly expressed in hepatocellular carcinoma and that its high expression increases the rate of lung metastasis and indicates a poor prognosis. Knockdown of FBL could significantly reduce proliferation and stemness as well as inhibiting the migration and invasion of hepatocellular carcinoma cells. Moreover, we found that FBL might be involved in the regulation of MYC and E2F pathways in hepatocellular carcinoma. Finally, we demonstrated that the knockdown of FBL could suppress hepatocellular carcinoma cell growth in vivo. In conclusion, ribosome-biogenesis-related proteins, especially Fibrillarin, play important roles in lung metastasis from hepatocellular carcinoma.