Background: Metastasizing ovarian cancer (EOC) cells anchor in the submesothelial collagen matrix. Results: Modeling EOC metastasis with cells in three-dimensional collagen culture down-regulates an inhibitor of Wnt signaling, Dickkopf-1. Conclusion: Cell matrix adhesion can activate Wnt signaling in the absence of Wnt pathway mutations. Significance: Cross-talk between adhesion-regulated signaling pathways may fine tune tissue invasive activity.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.