Recently developed dynamic nuclear polarization (DNP) technology offers the potential of increasing the NMR sensitivity of even rare nuclei for biological imaging applications. Hyperpolarized 89 Y is an ideal candidate because of its narrow NMR linewidth, favorable spin quantum number (I=½) and long longitudinal relaxation times (T 1 Graphical abstractCorrespondence to: Carlos Platas-Iglesias; A. Dean Sherry. Supporting information and ORCID(s) for the author(s) for this article are available on the WWWundergttp://dx.doi.org/. HHS Public Access