The current research presents some principles and settings in teaching biostatistics. The purpose of study is to enhance the teaching of biostatistics in Russian medical schools and overcome some problems by applying new approaches and innovation techniques. The research included the questionnaire of students, teachers and postgraduates of the Altai State Medical University. There were applied different approaches and studying by means of learning system MOODLЕ with differentiated courses in biostatistics. Categorical data were analyzed using the chi-square test and a P-value less than 0.05 was considered statistically significant. The findings showed some new approaches and methods in education to improve the biostatistical competence of medical students. The changing in content of biostatistical course would increase students’ motivation if it were maximum approximated to the real medical cases. The analysis of the results proved that some approaches are more effective for teaching biostatistics. They allow students to study according to their personal educational goals and paths.