Apamarga (Achyranthes aspera Linn.) is one such herb which is extensively used in the Indian systems of medicine. In Rigveda 190 medicinal plants were described, in that Apamarga is one of the plant. In Yajurveda this plant find its reference as having Rakshoghna property. Atharvaveda extensively quoted references regarding Apamarga. This plant removes the vitiated doshas from the body hence the name Apamarga. The properties attributed to this plant in Atharvaveda are Krimighna, Sahasravirya, Rakshoghna, Rasayana, Arshoghna, Kshudha, trishna, marana, vishaghna, Ashmarinashan and Ojovardhan. Charka samhita explained Apamarga under Krimighna varga. Keeping its immense qualities in mind screening of antimicrobial activity has been carried out on selected stains of organisms. Disc diffusion method has been adopted for antimicrobial activity. Study reveals significant result of trial drug when compared with the standard drug.