Background: Triple-negative breast cancer (TNBC) is a subtype of breast cancer that does not have estrogen receptors, progesterone receptors, and HER-2 receptors. This subtype is found in 15-20% of all types of breast cancer, and it is often associated with a high recurrence rate and mortality after getting definitive therapy. The aim of our study is to investigate the clinicopathology of breast cancer in our center, where the majority were Bataknese.Methods: We evaluated the clinical and pathological characteristics of TNBC retrospectively from medical records data, from January 2017 to December 2019 with a total of 105 patients but only 79 patients had complete clinicopathological and immunohistochemistry data. This study was conducted in Murni Teguh Memorial Hospital, Medan, Indonesia. Results: From 79 TNBC patients, the average age at clinical presentation was 41-50 years group about 35 samples (44.3%). All patients had an invasive type of ductal carcinoma (100%). The majority of tumor size was T2 in 51 patients (64,6%), 83.6% grade 3 tumors. Both angioinvasion and lymph invasion were found in 48 patients (60.8%) while tumor-infiltrating lymphocyte (TIL) was found in 58 patients (73.4%), and 44 patients (55.7%) had lymph node metastases.Conclusions: According to some existing literature, TNBC showed more aggressive characteristics which are the same as our study. TNBC was diagnosed at young age, grade 3 tumors, having TIL which is very likely to occur distant metastases to lymph nodes.

BACKGROUND: Breast cancer is a malignancy in breast tissue from the duct or lobar epithelium. American Joint Committee on Cancer has specified important prognostic factors such as primary tumor size, regional lymph node status, and distant metastasis. Axillary lymph node status has been one of the most reliable prognostic factors in early breast cancer in women. Axillary lymph node dissection is an old method to identify metastasis in axillary lymph nodes and started being replaced by sentinel lymph node biopsy (SLNB). SLNB has been introduced as a minimal invasive procedure, but in Indonesia, this procedure cannot be done due to technology limitation. Grading tumor is one of the predictor factors that can predict lymph node metastasis. This predictor factor has been associated with sentinel lymph node metastasis significantly. AIM: According to this, we conduct this study to analyze the correlation between grading histopathology in breast cancer with sentinel lymph node metastasis to lower false-negative rate in SLNB using methylene blue dye. MATERIALS AND METHODS: In this study, we included 51 patients that qualified using inclusion and exclusion criteria. Then, sentinel lymph node metastasis and grading histopathology data were retrieved from the patient’s medical record. This data are analyzed using SPSS with Chi-square test. RESULTS: The most type of breast cancer in this study is invasive ductal carcinoma was found in 40 patients (78.4%). There are 22 of 51 patients (51.6%) with metastasis to sentinel lymph node, have Grade 3 in histopathologic findings. CONCLUSIONS: The statistical evaluation showed that there is significant correlation between grading histopathology and SLNB with p = 0.001.

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Aim: Sentinel Lymph Node Biopsy (SLNB) establishes as a gold standard for diagnostic lymph node involvement in early breast cancer. Most of the developed country does not have radiotracer and nuclear medicine facilities. Unless in Indonesia there is Methylene Blue as an alternative agent for SLNB. This study measure accuracy of sentinel lymph node biopsy as a single technique using the Methylene Blue test. Methods: This cross-sectional study enrolled 60 female patients with breast cancer stage I-II. We performed SNB using 2-5 cc of 1% Methylene-blue dye (MBD) injected to periareolar tissue and proceeded with axillary lymph nodes dissection (ALND). The histopathology results of sentinel nodes (SNs) and axillary lymph nodes (ALNs) analyze for diagnostic value assessments. Results: The identification rate of SN was 97.62 %, and the median number of identified SNs was 4 (2-7). Sentinel node metastasis was found in (19/60) % cases and % of them were macrometastases. The sensitivity and specificity of MBD were 91.67% and 96.67% respectively. The negative predictive value (NPV) of SNs to predict axillary metastasis was 96.67% (95% CI, 81-99%). Conclusion: Injection of 1% MBD as a single technique in breast cancer SNB has a favorable identification rate and predictive value.