Monkeypox is a zoonotic disease that was once endemic in west and central Africa caused by monkeypox virus. However, cases recently have been confirmed in many nonendemic countries outside of Africa. WHO declared the ongoing monkeypox outbreak to be a public health emergency of international concern on July 23, 2022, in the context of the COVID-19 pandemic. The rapidly increasing number of confirmed cases could pose a threat to the international community. Here, we review the epidemiology of monkeypox, monkeypox virus reservoirs, novel transmission patterns, mutations and mechanisms of viral infection, clinical characteristics, laboratory diagnosis and treatment measures. In addition, strategies for the prevention, such as vaccination of smallpox vaccine, is also included. Current epidemiological data indicate that high frequency of human-to-human transmission could lead to further outbreaks, especially among men who have sex with men. The development of antiviral drugs and vaccines against monkeypox virus is urgently needed, despite some therapeutic effects of currently used drugs in the clinic. We provide useful information to improve the understanding of monkeypox virus and give guidance for the government and relative agency to prevent and control the further spread of monkeypox virus.
Site selection is a critical strategic decision for inland nuclear power plants which have broad prospects of development. However, several shortcomings exist in current researches, such as the incomplete decision frameworks, the indiscriminately treated properties, and the information loss. To handle the above flaws, this study establishes a two‐stage site selection framework. In the first stage, the geographic information system and preselection criteria are applied to identify suitable alternative sites. And in the second stage, the interval type‐2 fuzzy PROMETHEE II and suitability criteria are utilized to rank alternatives and select the optimal site, where different preference functions are selected accordingly. Thereinto, the interval type‐2 fuzzy numbers are adopted to describe the uncertainty and vagueness in calculation, without being transformed to exact value. Finally, based on the proposed two‐stage decision framework, a case of Hunan, Hubei, and Jiangxi provinces is studied, to demonstrate its validity and practicability. The results show that S8 is selected as the optimal site for its strong government support, convenient fuel transport, and land availability. This study not only enriches the material databases for inland nuclear power plant site selection, but also offers theoretical reference for site selection studies of various objects.
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