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Huge benign tumors in the hands sometimes show aggressive nature clinically. We report the clinical features of patients with a large benign recurrent tumors in the hands. Methods:We retrospectively reviewed 139 benign tumors in hands excised by the authors between January, 2006 and March, 2012. There were 4 cases of huge benign tumors in hands that recurred after total excision. Results:The average initial tumor size was 5.3×3.3 cm and the average recurrent tumor size was 4.4×3.0 cm. The average period of recurrence from initial operation was 11.3 months. The pathologic findings involved one epidermal cyst, two fibromatosis, and one giant cell tumor of tendon sheath. Although radical removal of the tumors were successful, reoperation due to the tumor recurrence was required. Conclusion:Regardless of the tumor malignancy, a wide range of tumor resection and radiation therapy may be necessary in order to prevent the recurrence of tumors in the hand. Sufficient follow-up periods to determine recurrence were required.

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