Potent TRPV1 inhibitor SC0030 was evaluated for inhibitory effect on osteoclast differentiation, a main process involved in pathology of osteoporosis. Osteoclast differentiation inhibitory study suggested that TRPV1 inhibitor SC0030 would be beneficial for prevention.

Gra.ci.li.bac.te.ra.ce'ae, N.L. masc. n. Gracilibacter type genus of the family; suff. ‐ aceae ending to denote a family; N.L. fem. pl. n. Gracilibacteraceae the family of Gracilibacter . Firmicutes / Clostridia / Clostridiales / Gracilibacteraceae Based on the phylogenetic positions, G. thermotolerans and L. thermophila are clustered together between Collins's Clostridium clusters I/II and III. Thus, the family Gracilibacteraceae herein is represented and described by both genera. Species of the family Gracilibacteraceae are obligatorily anaerobes that are thermotolerant or moderately thermophilic chemoorganotrophs that require yeast extract for growth. Cells are straight to curved rods and occur singly or form chains. All contain Gram‐positive wall structure, but stain Gram‐negative. Cells contain flagella and are motile. Type genus: Gracilibacter Lee, Romanek, Mills, Davis, Whitman and Wiegel 2006, 2092 VP .

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Gra.ci.li.bac'ter. L. adj. gracilis slender; N.L. masc. n. bacter equivalent of Gr. neut. n. baktron rod or staff; N.L. masc. n. Gracilibacter slender rod, referring to its cell shape. Firmicutes / “Clostridia” / Clostridiales / “Gracilibacteraceae” / Gracilibacter Gram‐positive cell‐wall structure, but stains Gram‐negative. Slightly polymorphic rods. Obligately anaerobic, chemoorganotrophic, and thermotolerant . No spores have been observed under various conditions tested. Not resistant to heating at 80 °C for 10 min. DNA G + C content ( mol %): 43. Type species : Gracilibacter thermotolerans Lee, Romanek, Mills, Davis, Whitman and Wiegel 2006, 2092 VP .