Central Asia is prone to wildfires, but the relationship between wildfires and climatic factors in this area is still not clear. In this study, the spatiotemporal variation in wildfire activities across Central Asia during 1997–2016 in terms of the burned area (BA) was investigated with Global Fire Emission Database version 4s (GFED4s). The relationship between BA and climatic factors in the region was also analyzed. The results reveal that more than 90% of the BA across Central Asia is located in Kazakhstan. The peak BA occurs from June to September, and remarkable interannual variation in wildfire activities occurs in western central Kazakhstan (WCKZ). At the interannual scale, the BA is negatively correlated with precipitation (correlation coefficient r = −0.66), soil moisture (r = −0.68), and relative humidity (r = −0.65), while it is positively correlated with the frequency of hot days (r = 0.37) during the burning season (from June to September). Composite analysis suggests that the years in which the BA is higher are generally associated with positive geopotential height anomalies at 500 hPa over the WCKZ region, which lead to the strengthening of the downdraft at 500 hPa and the weakening of westerlies at 850 hPa over the region. The weakened westerlies suppress the transport of water vapor from the Atlantic Ocean to the WCKZ region, resulting in decreased precipitation, soil moisture, and relative humidity in the lower atmosphere over the WCKZ region; these conditions promote an increase in BA throughout the region. Moreover, the westerly circulation index is positively correlated (r = 0.53) with precipitation anomalies and negatively correlated (r = −0.37) with BA anomalies in the WCKZ region during the burning season, which further underscores that wildfires associated with atmospheric circulation systems are becoming an increasingly important component of the relationship between climate and wildfire.