Poststroke depression is a common psychiatric disease among stroke patients, can lead to higher disability and mortality rates in stroke patients, and there is a bidirectional relationship between stroke and depression (Medeiros, G.C., et al., 2020). Stroke increases the risk of PSD, and depression is an independent risk factor for stroke. Due to the high prevalence of depression, which seriously affects normal life, it is very necessary to effectively treat and prevent the occurrence of PSD. This paper will discuss the pathogenesis of post-stroke depression from both biological and social psychological perspectives. Only when the mechanism is clear, can more specific targeted therapy be carried out.

Migraine and depression are common diseases in clinical practice. The comorbidity of migraine and depression makes clinical symptoms more complex and variable, reduces the therapeutic effect of the disease and affects the quality of life of patients. In recent years, the correlation between migraine and depression has been confirmed. Consulting relevant literature, it is found that there are certain similarities and correlations between migraine and depression from multiple perspectives. This article will mainly describe the comorbidity, influencing factors, correlation of pathogenesis and treatment.

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Parkinson’s disease (PD) is currently the second most common neurodegenerative disease. The pathological features of PD are degeneration of dopaminergic neurons in the brain, which leads to motor retardation, rigidity, quiescence, tremor, postural instability, smell disorders, pain, sleep disorders, depression and other non-motor symptoms Although the etiology of PD is still not fully understood, the occurrence of oxidative stress has been closely related to the pathogenesis of PD for a long time However, as there are many side effects of known PD treatment drugs, and there is a lack of effective treatment means to control the disease by inhibiting oxidative stress pathway, controlling the progression of PD disease by inhibiting oxidative stress has become a new direction of modification therapy. At present, a large number of studies have focused on the process of inhibiting oxidative stress. In this paper, a brief review of previous studies was made to provide new clinical ideas for the treatment of PD.