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The high-yielding cyanoethylation ± hydrogenation strategy was used to prepare simple AB 2 monomers from natural amino acids. Third-generation peptide dendrimers were assembled from these monomers on a polyethylene glycol (PEG) resin by standard Boc peptide coupling methods. Preliminary conformational studies were conducted on these chiral peptide dendrimers by size-exclusion chromatography, optical activity measurements, and investigation of the solid-state properties. These peptide dendrimers have potential applications as drug-delivery agents, asymmetric catalysts, peptido-and protein mimetics, and new biomaterials.

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