The aim of this descriptive correlation research was to identify the factors influencing stress in caregivers of stroke patients in rehabilitation centers. The data were collected from 200 caregivers at three rehabilitation centers in B City from September 1 to 30, 2015. The data were also collected utilizing the Connor-Davidson Resilience Scale, the Caregiving Mastery Scale, the Medical Outcomes Study (MOS) Scale, and Burden Interview (BI) Scale. The data were analyzed using the SPSS Win 18.0 program. The factor with the greatest impact on stress was social support, which accounted for 9.3% of stress, followed by the duration of giving care to the patient, religious status, economic conditions, caregiver's age, resilience, caregiver's health status, patient's conscious status, and patient's age, all of which accounted for 30% of the stress for caregivers. Therefore, it is essential to develop social support programs that can reduce the stress for caregivers of patients in rehabilitation centers and to develop stress intervention programs, taking all the factors affecting stress into consideration.