AbstrakSepsis mengubah mikrobiologi saluran pencernaan, menyebabkan hilangnya flora komensal dan pertumbuhan bakteri patogen yang berlebih. Pemberian probiotik penderita sepsis dapat mengembalikan keseimbangan mikrobiota dan memiliki efek positif pada fungsi imunitas tubuh serta struktur dan fungsi gastrointestinal. Penelitian ini bertujuan untuk menentukan efek pemberian probiotik terhadap mortalitas, inflamasi intestinal, dan kadar imunoglobulin A (IgA) serum pada mencit model sepsis. Penelitian ini merupakan penelitian eksperimental laboratoris, dengan sampel 36 ekor mencit Balb/C jantan dibagi menjadi kelompok: kontrol, sepsis, dan sepsis+probiotik. Sepsis results in changes to the microbiology of the gastrointestinal tract, leading to a loss of commensal flora and an overgrowth of potentially pathogenic bacteria. Administering probiotics to sepsis patients may restore balance to the microbiota and have positive effects on immune function and gastrointestinal structure and function. This study was aimed to evaluate the effect of probiotic on mortality, intestinal inflammation and immunoglobulin A (IgA) serum level in mice model of sepsis. This study was an experimental research laboratory, with 36 male Balb/C mice were divided into: control, sepsis, and sepsis+probiotic groups. The study was conducted at Histology and Biomedical Laboratory, School of Medicine, Sebelas Maret University, Surakarta, in January to April 2012. Sepsis was induced in the male Balb/C mice using an intraperitoneally (i.p) injection of cecal inoculum (200 mg/ kgBW), for sepsis mice model and sepsis with probiotic. Control mice were not inoculation during the study.

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