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microbial metabolite with a structurally close resemblance to the bacterial cell-wall peptidoglycan peptides.1 The structure of 1 is unique, as compared with the well-known muramyl dipeptide (MDP, 2), in the respect that 1 is devoid of the glucosamine residue at the 0 terminal of the D-lactoyl side chain and instead carries the zneso-2,2'-diaminopimelylglycine residue at the 7-C terminal of the l>glutamic acid in 1. Of particular interest is its wide range of immunological activities despite the lack of the muramyl moiety which had, until recently, been considered to be essential for the biological activity.2,3 Therefore, it was considered that the 2,2'-diaminopimeIic acid in 1, like the muramyl moiety in 2, might be a major contributor to the unique immunoactivity. As part of a program on this natural product, we were interested in preparing the (1) (a) Isolation: T.

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