Precocious differentiation of convoluted tubules of the submandibular glands of mice was induced by daily injection of thyroxine, insulin, hydrocortisone and 5alpha-dihydrotestosterone from day 4 after birth. This treatment induced enlargement of the tubules and synthesis of secretory granules in the tubules. Treatment with 5alpha-dihydrotestosterone alone had no effect on enlargement of the tubules or synthesis of the granules. These findings suggest that, besides androgenic hormones, these three hormones are also involved in synthesis of granules in developing mice.

No abstract

Condensed mycelia just prior to the onset of fruiting of Lentinus edodes accumulated adenosine 3′,5′‐cyclic monophosphate (cAMP) 9.2 times that of non‐aggregated mycelia (control). Immature fruiting bodies also contained cAMP, 7.9 times that of the control, while cAMP content was low in mature fruiting bodies. The immature fruiting bodies contained the highest level of adenylate cyclase activity, i.e., 3 times that of the condensed mycelia, suggesting that the presence of a high level of cAMP is required for the onset of the fruiting and cAMP may be rather actively metabolized in the stage of maturing fruiting bodies.