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Results: Patients with macular disease produced significant delay of P100 latency and amplitude attenuation of the steady-state VECP, as compared with healthy subjects. P100 latency delay was less in patients with macular disease than in those with optic neuritis, while the attenuation rate of the steady-state VECP amplitude was similar between groups. Visual acuity was correlated with P100 latency and steady-state VECP amplitude reduction. Conclusions: Although the delay of latency was less in patients with macular disease than in those with optic neuritis, the electrophysiologic alterations that occur in macular disease demonstrate a potential for diagnostic value at the level of the retina.

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Objective: To determine the clinical features of 272 patients who were diagnosed with optic neuritis at an ophthalmological clinic in Japan. Methods: We reviewed the records of patients examined between January 1977 and late June 1999. Results: The ratio of women to men was 1.7 : 1. The mean age at onset was 35 years and 80.5% were unilateral. The most frequent complaint was a vision decrease in 82.4%. The disc appeared normal in 38.5%. The median visual acuity at onset was 0.1; it was 1.0 at the recovered stage. The mean time required for visual recovery was 92.3 days from the onset. The most common known cause of optic neuritis was multiple sclerosis (MS)(22.8%). The recurrence rate was 22.0% and the mean number of recurrences was 2.9. The time for the development of disc pallor was 124.8 days. Conclusions: We found no racial difference in the incidence of MS as has been reported between Caucasians and Japanese.