Here we describe four young Japanese women aged 25-33 years, whose clinical findings are characterized by episodic angioedema, marked leukocytosis with eosinophilia, benign course with spontaneous remission or low-dose prednisolone treatment. The recognized causes of eosinophilia, such as allergy, parasite, and collagen diseases, and the causes of edema, such as heart, kidney, and liver diseases, were ruled out. The findings in these patients are very similar to those reported as episodic angioedema with eosinophilia, which is clearly distinct from the so called hypereosinophilic syndrome. We suggest that this syndrome is not rare, and should be widely recognized as a new clinical entity for accurate and prompt diagnosis. (Internal Medicine 31: 470-473, 1992)

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KW-1062 120 mg was intramuscularly administered to five healthy adult volunteers. After 30 minutes, they presented 7.28 ig/m1 of peak blood concentration. Mean recovery rate in urine was 84.5% for 24 hours.When administered to three healthy adult volunteers every 12 hours for 5 days, no accumulation of the drug in blood was observed.Overall clinical efficacy rate of KW-1062 was 71.6% in the treatment of 95 cases with respiratory tract infections. 72.2% of 36 patients with chronic bronchitis or panbronchitis and 69.0% of 42 patients with pneumonia or bronchopneumonia responded well to the drug.Side effects were encountered with 11 cases (9.8%). The results obtained suggest that the drug is useful in the treatment of respiratory tract infections due to gram-negative bacilli.

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