We synthesized a new porous coordination polymer Cu[Cu(pdt)2], which shows relatively high electrical conductivity (6 x 10(-4) S cm(-1) at 300 K) by the introduction of electron donors and acceptors as building units. This compound is applicable as a porous electrode with high power density. In addition, this compound forms a triangular spin lattice and shows spin frustration.

The FGF receptors (FGFR) are tyrosine kinases that are constitutively activated in a subset of tumors by genetic alterations such as gene amplifications, point mutations, or chromosomal translocations/rearrange-

A new MVA-LCD using Polymer Sustained Alignment technology (PSA-LCD) has been developed. This technology can realize a stable alignment with protrusion free structure by polymer sustainment. PSA-LCD has established high brightness, high contrast ratio and fast response speed. IntroductionMVA-LCD (1) has excellent performance such as high contrast ratio, wide viewing angle, rubbing free process and so on. And subsequently developed alignment technology using minutely patterned ITO improved response time drastically (2) . However this technology still needed protrusions because the alignment became unstable without protrusions. We investigated many alignment technologies and focused attention on polymer technology well known as polymer-stabilizing technology. It has been applied to several mode LCDs (3)(4) except vertically aligned mode. We have tried to apply polymer technology to the vertically aligned mode for sustaining the alignment without protrusions.The structure of the minutely patterned ITO we already had developed, can control the tilt directions of vertically aligned liquid crystal molecules. We have developed protrusion free MVA-LCD by the combination of minutely patterned ITO we have developed and the polymer technology, and named it PSA-LCD. We report in this paper the advantages of PSA-LCD and results of 17-inch wide panel fabrication. 2.PSA technology Figure 1 shows the panel structure of conventional MVA-LCD. In this structure, the liquid crystal alignment is controlled by partially located protrusions and ITO slits. Therefore, the alignment in the intermediate region between the protrusions and the ITO slits are not controlled directly and the alignment is not strong enough.On the other hand in PSA technology, we can control the liquid crystal alignment over whole pixel area with the help of polymer layer formed on the surface of the substrate. Figure 2 shows the fabrication process to form the polymer layer. Appropriate concentration of UV curable monomer is added to negative liquid crystal and injected to empty cell. After that, some voltage is applied to the cell. Under this condition, the cell is irradiated by UV light. This process can form the polymer layers on the inside surface of the substrate. The polymer layer formed in this way has the ability to control liquid crystal alignment.In other words, the formed polymer sustains this predetermined alignment. So we can obtain stable predetermined alignment. To realize the uniform predetermined alignment, we applied the structure of the minutely patterned ITO. Figure 3 shows the Common electrode Protrusion ITO Slit Pixel electrode Figure 1. Pixel structure of Conventional MVA-LCD LC Molecule UV Light Figure 2. Fabrication process of polymer layer Monomer PI ITO Polymer layer V

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Agonistic antibodies targeting CD137 have been clinically unsuccessful due to systemic toxicity. Since conferring tumor selectivity through tumor-associated antigen limits its clinical use to cancers that highly express such antigen, we exploited extracellular adenosine triphosphate (exATP), which is a hallmark of the tumor microenvironment and highly elevated in solid tumors, as a broadly tumor selective switch. We generated a novel anti-CD137 switch antibody, STA551, which exerts agonistic activity only in the presence of exATP. STA551 demonstrated potent and broad anti-tumor efficacy against all mouse and human tumors tested and a wide therapeutic window without systemic immune activation in mice. STA551 was well tolerated even at 150 mg/kg/week in cynomolgus monkeys. These results provide a strong rationale for the clinical testing of STA551 against a broad variety of cancers regardless of antigen expression, and for the further application of this novel platform to other targets in cancer therapy.