Objectives: Smoking causes endothelial dysfunction, but it still remains unclear whether oral administration of anthocyanin brings benefits to endothelial function and redox states in young healthy smokers. We tested the hypothesis that supplement anthocyanin may rescue endothelial dysfunction and redox states in young healthy smokers. Methods: Young healthy male non-smoker (n = 8) and smokers (n = 14) were enrolled to measure the derivatives of reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) levels and brachial artery flow-mediated dilation (FMD) before and 2 hours after one cigarette smoking or resting under administration of blackcurrant supplements (anthocyanins 210 mg) or not. Results: FMD, d-ROMs, and BAP at baseline were similar between non-smokers and smokers. One cigarette smoking induced a decrease in FMD at 2 hours (9.0% ± 2.6% vs 7.5% ± 2.3%, p < 0.05) without affecting plasma levels of d-ROMs and BAP in young healthy smokers. Single oral administration of anthocyanin at 210 mg abolished smoking-induced decrease in FMD (8.3% ± 3.4% vs 9.5% ± 3.6%, p = ns) without changes in plasma levels of d-ROMs and BAP in young smokers. In non-smokers, however, administration of anthocyanin at 210 mg slightly but significantly elevated plasma level of d-ROMs at 2 hours (249.6 ± 30.3 vs How to cite this paper: Yoshizaki, A., Tomisawa, T., Osanai, T., Nanashima, N., Kitajima, M., Mikami, K., Fujita, T., Maeda, H. and Kato, Y. (2018)

A super-resolution method for simultaneously realizing resolution enhancement and motion blur removal based on adaptive prior settings are presented in this article. In order to obtain high-resolution (HR) video sequences from motion-blurred low-resolution video sequences, both of the resolution enhancement and the motion blur removal have to be performed. However, if one is performed after the other, errors in the first process may cause performance deterioration of the subsequent process. Therefore, in the proposed method, a new problem, which simultaneously performs the resolution enhancement and the motion blur removal, is derived. Specifically, a maximum a posterior estimation problem which estimates original HR frames with motion blur kernels is introduced into our method. Furthermore, in order to obtain the posterior probability based on Bayes' rule, a prior probability of the original HR frame, whose distribution can adaptively be set for each area, is newly defined. By adaptively setting the distribution of the prior probability, preservation of the sharpness in edge regions and suppression of the ringing artifacts in smooth regions are realized. Consequently, based on these novel approaches, the proposed method can perform successful reconstruction of the HR frames. Experimental results show impressive improvements of the proposed method over previously reported methods.