Amaryllidaceae occupies a prominent position among the most important alkaloid-rich plant families in the globe. Plants of this family show an exceptional ability to produce a myriad of structurally diverse alkaloids with noteworthy pharmacological and therapeutic potential. Of these alkaloids, narciprimine is a rare weakly basic phenanthridone alkaloid that was identified from some species belonging to the genera Cyrtanthus, Galanthus, Lycoris, Narcissus, and Zephyranthes. This alkaloid has attracted a lot of scientific attention in recent years thanks to its biological properties, including cytotoxic, anticancer, and anticholinesterase activities. Hence, this review affords a comprehensive focus on the chemical, spectral, and biological attributes of narciprimine; providing a future perspective for possible research on this valued Amaryllidaceae alkaloid.