Multi-stage horizontal well fracturing with several perforating clusters in each stage is an important completion technique in tight gas and shale gas reservoirs. Due to the stress field interference, different perforation parameters and unevenly distributed cluster distance lead to individual fracture pressure, which determines whether the clusters can all be initiated during the fracturing process. The ABAQUS software can be used to create the 3D finite element model of horizontal multi-stage fracturing with several clusters and to analyze the fracture pressure influenced by different parameter set of helix perforation, such as phase angle, tunnel diameter, tunnel depth and perforating density. Based on the results of perforation parameter analysis, the simulation method can be validated with actual treatment data from Jilin oil field.