The purpose of this study was to determine the effect of the Tai Chi exercise program (Sun style 31 forms) on fatigue, anxiety, and sleep patterns in nursing students. Methods: A quasi-experimental study with a non-equivalent control group pretest-posttest design was used. Nursing students who participated in this study were assigned to an experimental group (n=24), and a control group (n=26). The experimental group participated in Tai Chi exercise program for 60 minutes per session, and 3 times a week for 7 weeks. The Tai Chi exercise program consisted of 10 minutes for warm-up, 45 minutes for main session, and 5 minutes for cooling down exercises. The data were collected prior and after the intervention using self-administered questionnaires. Data were analyzed using descriptive statistics, x 2 -test, Fisher's exact probability, t -test, and the general linear model. Results: After the application of the program, the experimental group showed a significant difference in fatigue (F=20.62, p<.001), anxiety (F=16.96, p<.001), and sleep pattern (F=15.70, p<.001) scores. Conclusion: These findings show that the Tai Chi exercise program can be an effective nursing intervention to improve sleep pattern and to reduce fatigue and anxiety in nursing students.