Background: This study was conducted to identify factors affecting perceived stress for cancer patients. Methods: A total of 104 cancer patients in a university hospital located in J province were participated. After IRB approval, the study period was between April and September, 2017, and the data were collected using by structured questionnaires. Collected data were analyzed by descriptive analysis, t-test, ANOVA, Pearson's correlation, and multiple regression using SPSS 22.0 statistical program. Results: The average score of uncertainty, resilience, and stress were 96.17, 88.54, and 17.76. As resilience, there were significant differences by spouse (t=−2.042, p=.044) and pain. As stress perceived, there were significant differences by spouse (t=−2.304, p=.023) and pain (t=2.097, p=.038). There were significantly positive correlations stress and uncertainty (r=.286, p=＜.001). In addition there were significantly negative correlation between stress resilience (r=−.287, p=.003). In this study factors affecting stress perceived were spouse (β=.337, p＜.001),resilience (β=−.335, p ＜.001), pain (β=.206, p=.023) and uncertainty (β=.204, p=.022). The factors explained 32% of perceived stress. Conclusions: Therefore, it is suggested that strategies of pain management and nursing intervention for strengthening emotional support including uncertainty and resilience management for cancer patients.