The
dichalcogenation of imidazoheterocycles led to the first functionalization
of imidazo[1,2-a]pyrimidine cores on the C6-position.
The methodology, involving iodine/dimethylsulfoxide oxidation of diaryldichalcogenides,
started with C3-chalcogenation, followed by C6 selanylation, activated
in acidic medium. This novel sequential dichalcogenation strategy
proceeded efficiently with excellent regioselectivity and yields.
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