The caveolin scaffolding domain mediates the promigratory activity of Src-phosphorylated (on Y14) caveolin-1 and, specifically, regulation of vinculin tension in focal adhesions. This suggests that pY14Cav1 enhances cancer cell migration by promoting engagement of focal adhesion traction.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.