Tacrolimus, a novel immunosuppressant agent, has been widely used in organ transplantation and autoimmune diseases. We herein present a case of neuromyelitis optica spectrum disorder (NMOSD) combined with Sjögren's syndrome (SS) successfully treated with tacrolimus. This patient repeatedly presented with recurrent longitudinally extensive transverse myelitis. Her NMO-IgG and anti-SSA and anti-SSB antibodies were seropositive. Considering the frequency of relapses and severe disability, tacrolimus was initiated after failure of intravenous cyclophosphamide. Her status was steady for over 36 months after tacrolimus treatment. This report indicates that tacrolimus may be a potentially effective immunosuppressant for NMOSD with systemic autoimmune diseases.

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An M/PH/1 queue model with catastrophes is regarded as a generalization of an M/M/1 queue model with catastrophes. Whenever a catastrophe happens, all customers will be cleared immediately and the queuing system is empty. The customers arrive at the queuing system based on a Poisson process and the total service duration has two phases. Transient probabilities of this queuing system is considered by means of practical applications of the modifified Bessel function of the fifirst kind, the Laplace transform and probability generating function techniques.

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According to the spatial distribution characteristics of the network is divided into sections and intersections of City road-network , according to the distribution of traffic flow characteristics an reference of relevant standards at home and abroad, the city traffic sustainable development degree is divided into 5 grades, selected the city sustainable development indicators, using analytic hierarchy process to establish traffic sustainable development two level evaluation index system and the corresponding fuzzy comprehensive evaluation model, and finally to a specific network traffic can develop continuously undertook determining. The research results for the assessment of city traffic sustainable development provided a kind of effective quantitative analysis method. At present, the city traffic sustainable development quantitative description has no unified standards, mainly to saturation, speed, density or fleet retention length to judge, although these amount to a certain extent the road network traffic can develop continuously undertook certain expressions, they don't reflect the traffic sustainable development-what is the essence of the road traffic is a serious waste of resources, or imbalance of traffic order. Transport aims to make people and objects are efficient, fast, convenient moving, but regardless of is the saturation, or speed or density are not accurately, effectively describe network traffic sustainable development degree, then based on the concept of traffic congestion mitigation strategy is also not really solve the congestion problem ] 6 1 [ −. Therefore, it is important to Judge network traffic sustainable development research, it can provide traffic management departments by accurate traffic data. Appropriate to the outlet of network traffic sustainable development measures, can provide a meaningful reference, avoiding the city traffic construction expands blindly and money and waste of resources.