The relationship between the vitamin D receptor gene (VDR) variants with serum 25 OHD3 con centration, body height (BH), body weight (BW), and body composition were examined in the Komi ethnic group. The FF genotype was associated with higher BW (p = 0.002) and lower bone mass (BM, p = 0.06) in comparison to the Ff genotype carriers. The BB genotype carriers were characterized by lower BL compared to those with Bb genotype (p = 0.037); BM was lower among those having bb rather than Bb variants (p = 0.025). No differences in the 25 OHD3 content were revealed. The results are consistent with the data obtained for populations from North Western Europe and opposite to those reported for tropical and sub tropical Caucasians, as well as for non Caucasians groups.

The goal of this study was to analyze the relationship of the blood serum apolipoprotein E (apoE), total cholesterol (TC), triglycerides (TG), and high and low density lipoproteins (HDLP, LDLP) levels with the body mass index (BMI), relative body surface area (RBSA), and the body muscle (BM) and body fat (BF) amounts. The study was carried out in male and female subjects aged 14-16 years (adolescent age group 1: n 1 M = 141, n 1 F = 151) and 18-25 years (young adult group 2: n 2 M = 141, n 2 F =46). No significant correla tions of serum TG and HDL with the somatometric indices were found. The TÑ content is positively corre lated with the fat component (r 1 = 0.164; r 2 = 0.418) and negatively, with the muscle component of body com position (r 1 = -0.165; r 2 = -0.352) in female subject samples. Blood serum apoE is significantly correlated with body composition (r 1 = -0.168 for BF; r 1 = 0.266, p < 0.05 for BM) in female adolescent subjects. These correlations are significant (p < 0.06) in male subjects aged 14-16 years. The TC and LDLP contents are neg atively correlated with RBSA (r 2 = -0.386 and -0.377, respectively) and positively correlated with BMI (r 2 = 0.413 and 0.415, respectively; p < 0.05) in young adult female subjects. With age, correlations between the fat content and apoE concentration change in female subject samples. The content of apoE decreases with increasing BF in female subjects aged 14-15 years; the correlation disappears in the age interval from 16 to 17 years. An increase in BF is accompanied by an increase in the apoE concentration in female subjects aged 18-19 years and older.

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