In order to study urban surface dust distribution, a three-dimensional model is proposed and the distribution of wind and the distribution law of air pollutants are researched. 3D campus of Shanghai University as a typical area is selected. The standard height (Twenty two meters) of teaching building for reference has been chosen. In different distances such as Eight、Twelve、Fifteen、Twenty meters, the amount and distribution of wind speed were obtained from simulation using FLUENT software. Combined with the particulate of air pollution’s distribution in urban surface, the optimized design of the main campus’s building spacing is analyzed. The results show that when the building space is about Fifteen meters, the concentration of pollutants and the distribution of wind speed is optimized.