S c i e n t i f i c R e s e a r c h I n s t i t u t e of Physico-Chemical M e d i c i n e M i n i s t r y of P u b l i c H e a l t h of t h e R u s s i a n F e d e r a t l o n , Moscow R e c i e v e d ; October 3, I Y M 6 ; R e v i s e d ; J a n u a r y 1 2 , l Y M 7 From t h e most a n c i e n t t i m e s p r a c t i c a l m e d i c i n e p o s s e s s e d two main methods of i n f l u e n c l n g a s i c k man: 1. i n t r o d u c i n g m e d i c i n e i n t o h i s i n t e r n a l media and 2. e v a c u a t i n g p o i s o n o u s o r s u p e r f l u o u s s u b s t a n c e s f r o m t h e body.e v e r y t h i n g t h a t l a c k s , and S u b t r a c t i o n of e v e r y t h i n g t h a t i s s u p e r f l u o u s .

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In vitro experiments showed that copper-oxidized low-density lipoproteins activate factors of the prothrombin complex in the whole blood and inhibit fibrin generation in both blood and plasma. Moreover, oxidized low-density lipoproteins inhibit fibrinolysis and impair the structure of fibrin clot, which results in hypercoagulation.

Fibrinogen intensified luminol-dependent chemiluminescence of blood leukocytes stimulated with opsonized zymosan. It is hypothesized that fibrinogen stimulates and prolongs functional activity of leukocytes during inflammation.

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