Background: Fibrosis in atrial myocardium is a common phenomenon for patients with atrial fibrillation (AF). Remodeling of connexins was found accompanying with AF. The aim of the study is to investigate whether it is by causing the remodeling of connexin 43 (Cx43) that the fibrosis of atrial muscle plays an important role during the initiation and maintenance of AF. Methods: Samples of right atrial appendage were taken from 24 patients with rheumatic valvular disease during surgery. Fibrosis and remodeling of Cx43 was examined by microscopy and ultramicroscopy technique and analyzed by image analyzer. The collagen volume fraction of type I (CVF-I) and the volume fraction of Cx43 (Cx43VF) were studied between AF and sinus rhythm (SR) groups. Results: (1) Microscopic examination demonstrated that CVF-I significantly increased and Cx43VF decreased in patients with AF compared to those with SR. (2) The CVF-I was negatively correlated with the Cx43VF. Conclusion: The results suggest that fibrosis and remodeling of Cx43 are involved in the pathophysiologic mechanism of human AF. Fibrosis of atrial muscle may play an important role in the process of AF by means of interfering with remodeling of connexins.

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Carry on unattended substation at the voltage of 220kV and the following is a technological innovation which having the profound influence to the current power supply system, is also the most important technology safeguard measure of the downsizing for efficiency in the power supply system. Along with the development of modern communication technology, computer technology, network technology, automatic control technology, image technology, monitoring technology and weak electricity integration technology, we had already realized the image and the sound signal's digitization, the audio and video signal's processing and the long-distance transmission. To the substation, besides the remote measurement, the remote signaling, the remote control, and the remote regulating functions which have already realized, the remote monitoring has also increased which called “five remote”. The “five remote” caused unattended substation become the reality and give a higher request to the information management and the intellectualization simultaneously. According to many years unattended substation's operational guidance experience, I proposed my ideas about the information management and the intellectualization of unattended substation, I hope that it is helpful to the promotion of the unattended substation.