No abstract

No abstract

No abstract

Investigation on electrophilic attaching of astatine-211 to methylene blue is carried out. Conditions for transferring astatine to a chemically active electrophilic form were found. A method for the production of astatine-211-tagged methylene blue has been developed. The resulting radiopharmaceutical preparation is free of the nonisotopic iodine carrier. The chromatographic method of purifying simultaneously the product by anion-exchange resin QAE-Sephades A-25 allows it to pass into a 0.9% solution of sodium chloride (physiological salt solution). The method provides the radiochemical yield of astatine-211-tagged methylene blue as large as 68+6%.

No abstract